Sang-Hwan Do
Seoul National Univeristy, South Korea
Title: Effects of intraoperative magnesium sulphate administration on the incidence of chronic postsurgical pain in patients undergoing total knee arthroplasty
Biography
Biography: Sang-Hwan Do
Abstract
Magnesium sulphate (MgSO4) is an effective analgesic adjuvant for acute postoperative pain. However, the effect of MgSO4 on chronic postsurgical pain (CPSP) remains unknown. We investigated this effect of MgSO4 in patients undergoing total knee arthroplasty (TKA) retrospectively. The operation was conducted by the same experienced surgeon under spinal anesthesia, unilaterally (n=355), staged bilaterally (n=489, at 1-week interval) or simultaneous bilaterally (n=31). The magnesium group received MgSO4 (50 mg/kg) over 15 min followed by a continuous infusion (15 mg/kg/h) during the operation. Medical records of a total of 875 patients [control group (n = 780) and the magnesium group (n = 95)] for 6 years (2012~2017) were reviewed retrospectively. In case of insufficient records, telephone interview was added. The incidences of CPSP at postoperative one year were compared between the two groups. The incidence of CPSP at one year after TKA in the magnesium group (7.4%) was significantly lower than that of the control group (16.4%) (P = 0.031). Intraoperative administration of MgSO4 was effective for preventing the occurrence of CPSP after TKA